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Guiding smarter drug design

Reveal crucial mechanisms of drug response with GenLinkResponse. Our platform maps drug-induced changes across chromatin networks, gene expression, and cellular pathways through integrated multi-omic analysis.

Decoding Drug-response Mechanisms

By analysing client-provided cell types treated with compounds of interest, we investigate epigenetic and regulatory changes with precision. Our 3D Multi-omic approach delivers delivers integrated insights into key areas, including:

Chromatin rewiring patterns

RNA expression changes

Chromatin accessibility alterations

Histone modifications

Pathway analysis

The Outcomes

  • Comprehensive maps of regulatory network rewiring in response to treatment.
  • Integration of evidence at multiple levels, including 3D multi-omics data, structural changes, and literature-based validation.
  • Tailored insights into cell-specific and allele-specific treatment-response patterns.

What We Enable

  • Identification of compound-induced changes in regulatory networks.
  • Identify unwanted drug interactions
  • Mapping of cell-type-specific regulatory landscapes, reveal differential treatment responses.

Applications of GenLinkResponse

Optimising Treatment Strategies

Design effective combination therapies and refine patient selection for targeted clinical trial success.

Biomarker Discovery and Validation

Identify and validate responder profiles to improve therapeutic outcomes

Toxicity and Safety Profiling

Predict and mitigate adverse effects through comprehensive drug response analysis.

Mechanism Insights and Research

Illuminate cellular pathways and uncover key mechanisms to advance foundational research and drug development.

Why choose GenLinkResponse?

Comprehensive

Integrates chromatin changes with multi-omics data for a holistic view of regulatory responses to drug treatment

Mechanistic

Maps genome-wide regulatory network rewiring to reveal how drugs affect gene-enhancer interactions and regulatory control

Cell-type Specific

Highlights treatment-induced regulatory changes unique to specific cell types

Actionable

Provides clear visualisations of drug effects across cell types via proprietary software

Cutting-edge

Utilises proprietary 3D Multi-omic technology

Unlock the full potential of the human genome

Whether you’re exploring disease mechanisms, searching for novel drug targets, or delving into fundamental biology, GenLink provides the regulatory insights you need to drive your R&D forward.

Discover Our Other Offerings

Want to see how GenLink can transform your research?

info@enhanc3dgenomics.com
01223 942520

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