Technology

Revealing causal biology at a genome-wide scale

Enhanced's proprietary 3D multi- omics platform decodes the function of the entire human genome to identify novel targets

Rapidly identifying new, high-confidence, first-in-class therapeutic targets for common diseases, 10x faster than other methods.

The platform is generating unparalleled genetically validated therapeutic targets, in the most relevant cell types, across the entire human genome to more than double the probability of drug development success.

10x

faster at identifying therapeutic targets

increase in drug development success based on genetic validation

ATGTTATGTAAATGGGATCTCGATCCGCTTAGCCCATAGAAAAGGGCCCGCTT ATGTTATGTAAATGGGATCTCGATCCGCTTAGCCCATAGAAAAGGGCCCGCTT ATGTTATGTAAATGGGATCTCGATCCGCTTAGCCCATAGAAAAGGGCCCGCTT ATGTTATGTAAATGGGATCTCGATCCGCTTAGCCCATAGAAAAGGGCCCGCTT ATGTTATGTAAATGGGATCTCGATCCGCTTAGCCCATAGAAAAGGGCCCGCTT ATGTTATGTAAATGGGATCTCGATCCGCTTAGCCCATAGAAAAGGGCCCGCTT

GTCGCTGATCGCTCTGAGAGAAAAGTCGTCGCCCAAAGGCCCTAGAGATAGCTCGT GTCGCTGATCGCTCTGAGAGAAAAGTCGTCGCCCAAAGGCCCTAGAGATAGCTCGT GTCGCTGATCGCTCTGAGAGAAAAGTCGTCGCCCAAAGGCCCTAGAGATAGCTCGT GTCGCTGATCGCTCTGAGAGAAAAGTCGTCGCCCAAAGGCCCTAGAGATAGCTCGT GTCGCTGATCGCTCTGAGAGAAAAGTCGTCGCCCAAAGGCCCTAGAGATAGCTCGT GTCGCTGATCGCTCTGAGAGAAAAGTCGTCGCCCAAAGGCCCTAGAGATAGCTCGT

GCGAGGAATTAGAAATGCTCTAGTAGATGATAGATAAAGTCCTAGATAGAAAA GCGAGGAATTAGAAATGCTCTAGTAGATGATAGATAAAGTCCTAGATAGAAAA GCGAGGAATTAGAAATGCTCTAGTAGATGATAGATAAAGTCCTAGATAGAAAA GCGAGGAATTAGAAATGCTCTAGTAGATGATAGATAAAGTCCTAGATAGAAAA GCGAGGAATTAGAAATGCTCTAGTAGATGATAGATAAAGTCCTAGATAGAAAA GCGAGGAATTAGAAATGCTCTAGTAGATGATAGATAAAGTCCTAGATAGAAAA

GATAGAGAAAAAGTCGCCGAGATAGCCTGCTGATAAATAAGTTTCCGCTGCTT GATAGAGAAAAAGTCGCCGAGATAGCCTGCTGATAAATAAGTTTCCGCTGCTT GATAGAGAAAAAGTCGCCGAGATAGCCTGCTGATAAATAAGTTTCCGCTGCTT GATAGAGAAAAAGTCGCCGAGATAGCCTGCTGATAAATAAGTTTCCGCTGCTT GATAGAGAAAAAGTCGCCGAGATAGCCTGCTGATAAATAAGTTTCCGCTGCTT GATAGAGAAAAAGTCGCCGAGATAGCCTGCTGATAAATAAGTTTCCGCTGCTT

AAAATGCTAGAATAAGCTCCCTGATATAATAGTCGGGGTCCGATAAAGGGGAA AAAATGCTAGAATAAGCTCCCTGATATAATAGTCGGGGTCCGATAAAGGGGAA AAAATGCTAGAATAAGCTCCCTGATATAATAGTCGGGGTCCGATAAAGGGGAA AAAATGCTAGAATAAGCTCCCTGATATAATAGTCGGGGTCCGATAAAGGGGAA AAAATGCTAGAATAAGCTCCCTGATATAATAGTCGGGGTCCGATAAAGGGGAA AAAATGCTAGAATAAGCTCCCTGATATAATAGTCGGGGTCCGATAAAGGGGAA

GATAAAAGCTCGCGCCCCCGATAGAGATGCTCGCTGCTCGTGGAAAGAATAG GATAAAAGCTCGCGCCCCCGATAGAGATGCTCGCTGCTCGTGGAAAGAATAG GATAAAAGCTCGCGCCCCCGATAGAGATGCTCGCTGCTCGTGGAAAGAATAG GATAAAAGCTCGCGCCCCCGATAGAGATGCTCGCTGCTCGTGGAAAGAATAG GATAAAAGCTCGCGCCCCCGATAGAGATGCTCGCTGCTCGTGGAAAGAATAG GATAAAAGCTCGCGCCCCCGATAGAGATGCTCGCTGCTCGTGGAAAGAATAG

An integrated approach to causal biology

The platform is generating unparalleled genetic validation of disease-relevant targets, in the most relevant cell types, across the entire human genome to more than double the probability of drug development success.

3D Genomics

Our proprietary platform analyzes genome folding at high resolution, linking gene enhancers and non-coding genetic variants to their target genes across the entire genome simultaneously. This reveals causal biological networks and unlocks the potential for first-in-class blockbuster therapies.

Multi-omics

Our multi-omics framework integrates gene expression, chromatin accessibility, epigenetic regulation, and protein-level activity to reveal how each layer shapes gene function in health and disease. By combining these data modalities within the context of 3D genome architecture, we can pinpoint the regulatory events, pathways, and cellular mechanisms that link genetic variation to biological outcome.

Our Technology

GenLink™ Platform

Our 3D multi-omics platform (GenLink) is the only genome-wide, hypothesis-free technology able to translate massive amounts of disease-associated variant data into causal biology on a cell-type-specific basis.

Our Technology

GenLink™ Platform

Our Technology

GenLink™ Platform

Translating Variant Data Into Function

Our 3D multi-omics platform is the only genome-wide, hypothesis-free technology platform that can translate massive volumes of disease-associated variant data into causal biology on a cell-type-specific basis to illuminate new causal biology and provide opportunities for truly disease-modifying therapies to be developed.

Target Identification

Increasing the number of novel disease targets discovered

Faster Discovery

Reduced timelines compared to conventional approaches

Impactful Therapeutics

New causal biology enables new first-in-class medicines

Cell-type-specific Medicines

Illuminate dysfunction in the precise cells that drive disease

Turning Genetic Insights Into Drug Targets

Our discovery engine translates decades of genetic data into actionable, high-confidence targets by mapping how disease-linked variants disrupt gene function at genome-wide scale.

Starting with a sample of (healthy) cells

We begin with carefully selected healthy human cell samples that provide a clean biological baseline.

Generating deep multi-omic and 3D genomic data

Building the integrated 3D multi-omics atlas

Querying GWAS variants against the atlas

Triaging and validating high-confidence targets

Turning Genetic Insights Into Drug Targets

Our discovery engine translates decades of genetic data into actionable, high-confidence targets by mapping how disease-linked variants disrupt gene function at genome-wide scale.

Starting with a sample of (healthy) cells

We begin with carefully selected healthy human cell samples that provide a clean biological baseline.

Generating deep multi-omic and 3D genomic data

Building the integrated 3D multi-omics atlas

Querying GWAS variants against the atlas

Triaging and validating high-confidence targets

Turning Genetic Insights Into Drug Targets

Our discovery engine translates decades of genetic data into actionable, high-confidence targets by mapping how disease-linked variants disrupt gene function at genome-wide scale.

Starting with a sample of (healthy) cells

We begin with carefully selected healthy human cell samples that provide a clean biological baseline.

Generating deep multi-omic and 3D genomic data

Building the integrated 3D multi-omics atlas

Querying GWAS variants against the atlas

Triaging and validating high-confidence targets